Persuasive Speech on Social Networking Essay

Since the Internet has rapidly propagated, social media has progressed rapidly. The widespread use of mobile devices to access the internet gradually transformed the nature of our social interactions. Most people use smart phones, iPhone or mobile internet devices to easily access social network. Since the function that people can interact online through social media, chat or share information with each other. It helps us contact friends, family, and other people even if they live far away. The service they can receive by using it are very impressive, most of people have their own account for participating. Although social media leads people to have more interaction and promotes long-distance relationships, it has a lot of bad things that make us out of control. see more:social networks and our young generation. Many of social media users are addicted and they became more isolated by using social media. Social media has many advantages; nevertheless, it can be abused in moments by young children if we are not careful, because they can easily access social media. We need to understand and regulate the use of social media by young children. My own view is that we should understand and regulating the use of social media by young children, because overusing social media can create strong addictions, develop mental or physical disorders, and waste our time. First of all, social media, such as Facebook, are very addictive. Especially, people who are lonely can become easily addicts. Human is social animal, so they want to make relationship with others. People would say drug or alcohol is more addictive and harmful for children than social media; social media addiction is not a big problem. Unfortunately, it is not true. Social media can lead to compulsive behavior. A report of the social media addiction by University of Chicago’s Booth School of Business says: â€Å"There is evidence to show as well that social behaviors like hugs and smiles are associated with dopamine release †¦ it’s possible that social media is pleasurable and becomes addictive via the dopamine mechanism just as drugs or alcohol can.† In the light of these facts, surely social media can make addicts, and it is hard to escape. The problem is most people who have an addiction to social media and do not even realize it. Children, also, can easily get mental and physical disorders through using social media. People might think social media does not contribute to disorders. They argue that social media is good for mental diseases because it help them express their  feelings or thought easily. Also, through social media, they can be more connected with each other. However, as stated above, if children become addicts, naturally we could think they have emotional instability. Social media offers limited real interaction, through online contact. On the Mental Health Blog, psychologist, Aric Sigman claimed â€Å"Spending too much time online could lead to social isolation, loneliness and a negative outlook. These types of psychological symptoms could eventually lead to more serious health concerns, such as heart disease, cancer and dementia. (Sigman)† Using social media disturbs make deep relationship with others. When they are using social media they do not need to move or be active. As a result, it leads to mental and physical disorders. Social media can become handicap in our life. In this sense, social media can hinder people to improve their talents. People think social media is good place to show their talents or works what they did. For example, they argue people can share video clip what they playing the instruments or dancing or singing. However, if you are not good at those things and if you spend time to do social media, it would be hard to improve your talents. Using social media steals your time what really want to do. If you do not pay attention, your time would go very fast, and it could not be returned. If you read books, or study, exercise, or practice something that you want to do instead of using social media, it would be much better for you and your future life. I conducted surveys about relationships between using social media and studying last semester. Most students answered using social media is not helpful for studying. Also, students who got good grades spent just a little time to use social media. These results can be adjusted to young children because they are more easily influenced by social media. Especially, the young generation and children are easy to be exposed to environments which using social media. Social media are favorite not only along with teens or youngsters; it is growing among working people and also adults. Social media is regarded as an addiction and many people are becoming addicts every day. It can occur mentally and physically and make  you waste time. As you can see, we need to understand and regulate the use of social media by young children. The most famous social networks, YouTube, Facebook and Skype are included. It is important to know why people have to use social media carefully and need some restrictions when using it. Many people love social media because of its wide connectivity and functions that people can receive it for free; it does not require money to make an account and use it. Facebook is the most visible among various social media. First thing that people get impressed is, Facebook makes possible to create a deep networking between users. Since each user has a right to accept or refuse the friend request, the interest by people is high enough. Moreover people tend to allow the other’s friend request who have same thoughts and characteristics, by this reason it is able to maintain an intimate relationship. Not only users can leave comment on other’s post and the other user reply to that comment, by doing this continuing communication can be accomplished. So, it is a same response of users that deep networking can be made naturally. The second benefit is, it is good in long distance relationship. The survey from the â€Å"Telegraph† which is a famous newspaper in United Kingdom, tells that Social networks such as Facebook are helping to inspire a boom in long distance relationships. The number of people who have a partner that lives mor e than two hours away increased about twice in the last 10years. Three quarters of them say that by using social network such as Facebook and MySpace where everything can be shared, they were able to maintain their long-distance relationship. In my case, I am not living with my family. I live in Utah and my family live in Korea. It is hard to contact each other and I cannot know what my family is doing their country and also they do not know what I am doing in this country. But after we started to use Skype, we can check each other what we daily do. If I want to see my family’s face, I can see by using videophone. Even though I and my family live far away about 5500miles, we can check each other’ status whenever we want because of development of social media. Even if Facebook and MySpace, those kinds of social media have various advantages, it receives less attention than the bad effects of social media. The most serious problem of social media is addiction. One reporter described that â€Å"Text messaging is no longer the biggest t eenage obsession, and long gone are the days where the biggest worries for parents were celebrity crushes, massive phone bills from  ridiculously long phone calls and chocolate overloads. These teenage obsessions still exist, but in today’s day and age, and in comparison to the Facebook craze, they seem rather insignificant This huge issue also applied to me and my friends. When I came to Utah first, I had a hard time conversing with the people in this country. For learning English I decided to do Facebook rather than reading books or watching television, which is effective but not fun method. Because of Facebook’s worldwide connection, I was able to have more time and chance to communicate with my school friends. Soon, I could talk with Utah friends about private things and school work. As my relationship gets stronger, the time I spent doing Facebook extended, chat on-line and do applications already took a place in my life. I felt logging on Facebook was the best time ever in Utah since it helps me to learn language, to make friends, and to escape from boring life on abroad. But, the problem began with doing Facebook actively. My primary work of the d ay was doing Facebook. I preferred doing Facebook more than any other important work, including doing homework, exercising, sleeping, and even going to school. When I realized there was a problem, it was after I was addicted to Facebook. With my cousin’s help I could get away from Facebook, the dangerous social network. But some of my friends are still suffering from a Facebook with addiction. Another thing is that some person becomes lonelier after using social media. Most people might think that because social media have a benefit that give more opportunity to people to have more interactions through social network, people can strengthen relationship with their friends by chatting and leaving comments on each other’s wall and even people could make new friends by online meeting. Opposed to their thoughts, it is not. According to interview with Dr. John Cacioppo, who is a professor in neuroscience at the University of Chicago, tells that â€Å"â€Å"You can end up online so much that you end up sacrificing face-to-face contact. Having 4000 friends on Facebook might make you feel that you have lots of friends, but you have no face-to-face contact. In that case, loneliness INCREASES (Johnson).† It is not possible to make real relationship if people do not meet face to face. The people who were not talkative and social would be worse. One of my friends could example of this. He was poor at interacting with friends, he could not participate in our conversation and if we initiated a conversation, he stepped behind and went to his place. After he started using social media, the number of interaction with friends decreased. And he even did not make new friends through social media and he became less social. It led him to feel more loneness and seriously he tried to suicide once. It was one of happening events around me result of using social media. It is a really serious problem in this society. It is related to human’s life. This big problem is not facing to us. In conclusion, although social media has lots of benefits that are attractive and helpful to us, it usually gives more harmful influences than good effects. Like an addiction and fraud advertising, it is not anymore a small problem that can be ignored. To make better future, it is really important to use social media carefully. All things are depended on you.

American Psychological Association Ethical Code Essay

A Code of Ethics can be an overly complicated document that seeks to embrace every detail of behaviors that will not be acceptable to senior company management if found out. Meanwhile employees are pressured to deliver results which will often be enhanced if they do not strictly adhere to the Code of Ethics. The contention is that ethical codes are important to the organization; there is an ethical code, so the organization must be ethical. To the employee, it defines boundaries so they know when they are crossing them. Not all ethical codes are equal. If they protect employees from breaching some unwritten code, then they are good and fair. They must also be applied rigorously to senior management. It is normal for people who make rules to think that they should apply to others more than themselves, and that’s not a healthy way to look at it. As we have all learned, rules should apply to everyone for them to be just. If rules are made for only a certain group of people within an organization, the balance of power tips to one side unfairly and it leaves the organization and its consumers open to ethical breaches. My source showing why codes of ethics are important.  Ingram, David. â€Å"Importance of Creating a Code of Ethics for a Business.† Small Business. Houston Chronicle, 2014 Codes of ethics are very important because it guides decision making. It creates a cohesive understanding boundaries within an organization and it sets standards for interacting with external people. A well written, formal code of ethics can reduce ambiguity of certain rules and can serve as a guideline for making tough, and often controversial decisions. A code of ethics also plays an important role of protecting a companies and its employee’s reputation and where it stands legally when there is a breach of ethics by an individual person. A good code of ethics helps avoid not knowing what to do when one is confronted with a big dilemma. When a code of ethics is written for businesses that operate overseas and/or in other countries, it can be vital that an organization abide by the code of ethics to avoid a very unfortunate  misunderstanding in another country that may have drastically different views than your own. As I have shown, it is critically important for an organization to have a formal, well written code of ethics to set ethical standards for individuals within the organization. That way, when an individual breaches that ethical code, the organization can fall back on that code of ethics and say that what that individual did goes against the organizations standards. So generally codes of ethics are good, and needed. They serve a critical purpose in most organizations and serve as a guideline of how to conduct business. It safeguards the company against breaches of ethics because they have their own code of ethics that are written and can show it to prove where they stand whenever their standards are calle d into question. My source showing what’s wrong with codes of ethics.  Lunday, Jason. â€Å"Codes of Conduct: Typical Weakness and How to Overcome Them This article highlights what can be wrong with codes of ethics. One of the main problems with codes of ethics is that they may not be well constructed and not specifically address the companies specific needs and characteristics. Sometimes the standards in the code of ethics don’t clearly specify what an employee should do with certain challenges, and can sometimes put an employee in a dilemma abiding by the standards and suffering the consequences, or going against the code to get the job done. Many employees have indicated that codes of ethics are written with good intentions and convey good intentions, but most of the time they do not acknowledge the realities and practicalities of the business environment. Some codes of ethics can set the wrong tone and seem too vague or even too legalistic. Employees have stated that some codes of ethics seem to be protective of top management rather than the whole company, especially those at the lower levels. What I have noticed with some codes of ethics is that they do sound too legalistic and they leave a lot of the common sense topics out. Most codes of ethics do not include advertising, but most companies advertise in some way. Some codes of ethics are created with benchmarks of other companies codes of ethics. When this happens, an organizations code of ethics might sound and look great, but it doesn’t fit their specific purpose and doesn’t address some of the most important aspects of the organization. One Strength of the Code of Ethics. Psychologists are involved in the difficult area of human behavior. On a daily basis they are dealing with people whose view of the world has often been distorted by their history. They may begin to lose their own guideposts. The Code of Ethics is a reference that can be consulted to make sure the psychologist does not stray from a moderate behavior path. If it creates conflicts for the practitioner the relevant Ethics Code can be taken up with a supervisor allowing for discussion and interpretation. One Weakness of the Code of Ethics The Council of Representatives of the APA developed the code. Anytime you have a committee design something you are likely to complicate it. Each representative has their own world view and in a committee setting feel they have to contribute more. The weakness is that adding more detail rather than making issues clearer can make them ambiguous. There are Ten Commandments in the bible and 89 ethical standards set by the APA. One thing I saw and did not expect I did not expect that the Code would exclude application to practitioners outside of work activities. While legally the Code probably cannot be enforced outside of work, if the Code is silent on that point it would imply that this should be a personal code anyway. By stating that it does not apply outside of work it implies that practitioners have to be on their best behavior at work and not the way they might behave outside of work. This weakens the practice of the code. An example of when the code might be used. Standard 3 is a key Code in this line of work. As the patient has life issues their gratitude for help and verbal intimacy with the practitioner may lead to a relationship. The Code of Ethics is a reminder to not let this happen. While the Code of Ethics is restricted to work activities this area should apply if practitioner is in a work situation or not. Explanation of why the code would be used As in all occupations. ‘Do no harm’ must be the key ethical position. As the brain is a largely unknown organ, psychologists have to be very careful about their treatment of mental issues. Their patients are at various stages of walking towards a personal precipice, the practitioner cannot afford to give an accidental push. Code 3.08 covers exploitative relationships between practitioner and patient and is the most likely violation of code which must be reported. As patients are having trouble with their own reality a suggestion from the practitioner may be seen as ‘normal’ by the patient but not by the ethical code. Works Cited American Psychological Association Code of Ethics http://www.apa.org/ethics/code/index.aspx# Ingram, David. â€Å"Importance of Creating a Code of Ethics for a Business.† Small Business. Houston Chronicle, 2014. Web. 28 Oct. 2014. . Lunday, Jason. â€Å"Codes of Conduct: Typical Weakness and How to Overcome by Jason Lunday.† Corporate Compliance Insights. 17 June 2010. Web. 28 Oct. 2014. .

Wayexplain How the Relationship Between an Organisation’s Structure and Culture Can Impact on the Performance of the Business

Character Analysis As we all known that the characters leading peoples’ behaviors and thought. In terms of characters influenced by environment and nurture, on the one hand, people do not believe that characters will affect when their make decision, one the other hand, characters will also determine peoples’ job position or the levels of life in the future. Now, let us talk about why characters are important in our life. Regardless of you believe that or not, characters are your label and when you fall in trouble or something happened that characters will make you predict your act.Even you are meeting new people, through the details when you are taking about that will help you making the levels about the person quickly. In fact, all of the details are reflect of peoples’ characters so that we are making character analysis everyday. In this essay I would like talk about my own characters and analysis it. Initially, I will talk about my own positive characters. By the way, my name is Mouzhi-young and my name was given to me by my grandfather. He want to me become an intelligence and ambition person. Of course, young is my family name.I am an easy-going man and I pleasure help others. When my friends get in trouble I always the first man is selected to. On the other hand I think my good quality consist by will power. The thing that I am decided I never give up. That means I will try my best to do. Sometimes my friends think I am a paranoia. Contrary, I also have some negative characters. Partly because of my name, my parents want to me become a useful and successful man so that they have too much wish for me. When I was a child, they ask for me attend a lot of course in the free time.I do don’t know why am I have to spend so much time to study. Then, I guess I hate study and I absolutely acknowledge that the real things are do what you want to do. So I guess I am an idealist. The reason is I do don’t care about others mind and I just care about myself. I won’t put myself in trouble. I think it is not selfish and it is the prefect way to protect myself. Similarly, I pleasure help my friends and I always do that. It is sometimes I just don’t know how to deal with the relationship with other people so that I make the opposite way to do that is try to diminish communication with others.There is important example about myself that I don’t feel like make other people clearly know about me. By my side, I afraid that other known about me too much on account of I am not good at explain and I also hate explain. I never ever try to know about others secrets, so I am wish other people would give me a free. After that, I guess I am too emotional and sensitive. I will profile every thing in my life. It is means I crazy about figure everything it out. g

Art Business - Is Contemporary Art a safe investment Dissertation

Art Business - Is Contemporary Art a safe investment - Dissertation Example The study "Art Business - Is Contemporary Art a safe investment" explores the contemporary art market and the method of investment in the art market and discusses whether it is safe to invest in the contemporary art market, also taking into consideration the traditional investment products. The international art market is particularly focused on providing the right values to art and antiques. The government has a significant role to play in this regard that supports the retailers involved in the system making it difficult to access. Although parts of the system are supported by the government, but such supports are highly effective. The art market is mainly dominated by two companies – Sotheby’s and Christie’s. However there is no duopoly in the system and hence no effect on the consumers nor is there any cartel for fixing of prices. While the contemporary art market has emerged as a type of investment for individuals, there are the traditional types of investmen ts still prevailing effectively in the markets. Financial markets are existent since traditional times offering several means of investments. Financial markets are normally differentiated depending upon the types of investments, their maturities, the investments being made by the types of borrowers and the ones who are lending, market locations, and the means and ways of conducting the transactions. The financial markets are varied with the most essential being the money markets, capital markets, debt markets, equity markets, primary markets., secondary markets, derivative markets, stock markets, and over-the-counter markets. These markets not only provide with investment measures but are also competitive with each other (Besley and Brigham 2008). The most common types of traditional investments include stocks, bonds, mutual funds, along with alternative investments such as Options, Futures, FOREX, Gold, Real Estate, and others (Investing 101: Types of Investments 2013). Over the la st ten years, there have been significant changes in the industry of investment management. Several new methods of investment and investment products have been developed along with alternative methods of investments attracting more and more number of investors. Such changes have taken place owing to the need to manage the changes occurring in the financial regulations information technology, and demands and preferences of the investors (Crowder, Schneeweis and Kazemi 2012). However, although there are several new methods of investment and products available for customers, the traditional investment methods are still popular and most people tend to use the conventional methods for making investments, of which stocks, bonds, and mutual funds are the

HomeLand Security Strategies Research Paper Example | Topics and Well Written Essays - 1750 words

HomeLand Security Strategies - Research Paper Example This reaffirms that America is committed to pursue its interests by the use of an international system where all countries have specific rights and responsibilities. The paper will discuss the homeland security strategies focused on the safety and security of the citizens of America. This is attributed to the fact that there have been enormous threats to American citizens than weapons of mass destruction, especially the danger posed by the pursuit of nuclear weapons by violent extremists and their proliferation to neighboring states. As noted by Reddick (2010) the National Security Strategy which was released in May, 27 2010 rolled out a strategic approach for the advancing American interests including the security of the American citizens, improving American economy, and supports their values, as well as an international order that tackles the challenges of the 21st century. The strategies include: Defeating terrorism globally After the September 9/11, terrorism attacks the United S tates has made significant steps in ensuring the safety of the nation. It formed the foundation of Department of Homeland Security (DHS), whose functions took a new organization and urgency. Their approaches now included: restricting hostile actors the capability to operate within the American borders; shared efforts to determine and interdict threats; maintaining effective control of our physical borders; ensuring national resilience in the face of the hazards and threats; safeguarding lawful trade and travel into and out of United States of America. The DHS and many of its partners locally, regionally, and internationally as well as the communities have strengthened the homeland security enterprise to mitigate and defend against dynamic threats. Their core strategic objectives include: comprehending the threat, deterring and disrupting operations, protecting against terrorist capabilities, stopping the spread of violent extremism, and increasing community participation in order to deter terrorists and alleviate radicalization towards violence. According to DHS (2012) it reported that its efforts to prevent terrorism are centered on a layered risk-based approach to the security in the cargo and passenger systems of transportation, borders, and ports of entry.   It consists of new technologies to: help detect explosives and other dangerous weapons; aid in the protection of critical infrastructure and cyber networks from attack; build partnerships in information sharing. According to Guiora (2011) found out that DHS works in corporation with many partners in countering violent extremists. These extremists cause a great threat to national security. The DHS has initiated the following programs to counter violent extremists: international partnerships with other countries like Canada, Spain, Belgium, and Germany; conducting joint workshops and conferences of law enforcement agents; and provision of grants to the support of law enforcement efforts. Terrorist acti vities that may occur due to explosives are cut out by DHS’s work through enhancing the counter-IED capabilities of the nation and reduce the threat of explosive attack. Moreover, terrorist activities are prevented through: building of the homeland security enterprise which has fusion centers, nationwide suspicion activity reporting initiative, presence of homeland security

Define Marketing Research Paper Example | Topics and Well Written Essays - 500 words

Define Marketing - Research Paper Example This feedback helped them to produce the goods in a new way – incorporating the features in reference to its utility, aesthetics and as per the needs and wants of the customers. The companies who incorporated this philosophy in their production planning process found that their sales are bouncing without any further need to hard sell the product. Sales people gradually became less important for the organization as marketing techniques came into the forefront. A strong marketing perspective virtually needs no sales person; the product sells on its own. Apple is the most glaring example of true marketing philosophy in recent days that has rocked the market. Currently, there is not a single product in the market place where marketing concepts are not employed. Relationship with the customer is built through product and services offered to them. The sales concept aimed at building the relationship through the efforts of sales person. In fact, a strong marketing vision needs to be at the place and the organization with orientation focused on sales only cannot survive in the current market situation. While marketing is so important for an organization; it is obvious that marketing plan is also equally important in an organization because the plan helps implement the marketing perspective of the company in a proper way to achieve desired results that the organization wants to achieve in the given time frame. Marketing plan has many important components such as mission, organizational objectives, SWOT analysis, setting assumptions, marketing objectives and strategies in line with organizational objectives, formulation of strategies, budgeting, and implementation program. The marketing plan has a lot of tactical details that spell out various actions to be taken in a given time frame with clearly defined responsibility on a person or group of persons. At times, marketing planners incorporate a strategic perspective too into the planning

Review of leterature Essay Example | Topics and Well Written Essays - 1500 words

Review of leterature - Essay Example According to Thompson & Fox (2010), the challenges faced while screening for postpartum depression from mothers from diverse cultural background can be overcome by the employment of an appropriate screening tool which can be identified by an expert nurse. Scott (1992) observes that postpartum depression has substantially profound impacts on the social morbidity of the child. Besides social morbidity, postpartum depression affects the individual’s psychological wellbeing (Scott, 1992). Consequently when an individual has psychological as well as social challenges, through the ripple effect the larger society is affected. This indicates how profound the problem failure of early detection and intervention of postpartum detection has to the general population. A research conducted examining the resulting mother-child bonding at one year provides important findings related to this research. The mother-child bonding was examined from two factors which affects it in the first few weeks, postnatal depression and bonding (OHiggins, Roberts, Glover, & Taylor, 2013). According to OHiggins, Roberts, Glover, & Taylor (2013), utilizing the Edinburgh Postnatal Depression scale (EPDS) and the Mother Infant Bonding Questionnaire (MIBQ), the researchers were able to successfully detect postpartum depression and provide the intervention needed. From the findings of the research, there was the indication of postpartum depression contributing profoundly to the bonding problems (OHiggins, Roberts, Glover, & Taylor, 2013). Consequently, the bonding problem affected the child’s behaviors negatively to a significant extent (OHiggins, Roberts, Glover, & Taylor, 2013). Multiple screening tools used in the detection of postpartum depression improve the ef ficacy of its detection. According to OHiggins, Roberts, Glover, & Taylor (2013), an improved

Accounting Case Study Example | Topics and Well Written Essays - 250 words

Accounting - Case Study Example Case in point, the author ought to get 80% of the tender. Redone showcasing battles are essential for this situation to enhance productivity. More also, it is central for the author to be dynamic in advancements. To expand eminences, books ought not to be sold straight forwardly to retailers on a refundable basis. Furthermore, short rebates are vital so as to augment sovereignties. Specifically, an organization can be spoken to through a blend of three primary components: 2) administration exercises, That can be recognized in operational and vital. Functional activities are normally short term situated and concentrated on proficient use of accessible organization assets (e.g., gear, human good). Control costs. The point of interest of controlling costs is that for each money you spare by reducing a price, there will be an additional money in benefits, Reduce promoting expenses, Manage your stock, Develop a database, Seek add-on deals (McGee and Preobragenskaya 2). Nearby its current item run; that Slim Choice embrace a crisp and sound picture and be advanced in the media utilizing thin, vigorous and youthful models; Dont stretch out credit to moderate clients. Diminish credit terms. Enhance endeavors to gather obligations i.e. enlist a debt gathering office. Offer rebates to right on time

Business Start Up Assignment Example | Topics and Well Written Essays - 1500 words

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Export and Import Research Paper Example | Topics and Well Written Essays - 1250 words

Export and Import - Research Paper Example The culture of instating clear regulations has been in the United States for a long time. This is done to ensure the safety of all the citizens of the country. Therefore, a business that will not consider such regulations is likely to flop. For example, the United States has clear regulations on any imports that pose a threat to the environment (Manresa, 2010). This is a culture that has been developed to ensure the nation does not pose environmental threats to its citizens. Apparently, the issue of globalization has enhanced the regulations that are deemed to limit the influence on the environment. In the previous years, the regulations on imports were not stringent, which was an easy task for importers and exporters. As such, there is a need to take a closer reflection on these regulations before embarking on the import and export business. Culture of a country determines the way of life of the citizens. Therefore, this is likely to affect the import and export business as it is likely to affect the demand of supply of the products in the country (Cook, 2012). For example, the issue of junk foods is prevalent in the United States. This is an issue that has caused uproar between concerned parties especially in regard to health concerns. It is estimated that many young citizens of the country have health issues which emanate from the consumption of junk foods. These are fast foods that are consumed frequently in the United States. ... In order to reduce such instances, there is a dreaded reduction on the production of such foods. This would be a setback to businesses that would wish to import and export foodstuff. Lastly, there is the culture of consumption of particular products. This should also be considered since the demand market will affect the business. Governmental, compliance management, and security requirements There are various institutions that are put in place to deal with the import and export business in the United States. These are institutions that ensure the business is conducted in a legal and safe manner (Manresa, 2010). First, there is the Border Compliance Assistance Center which is instrumental in regulating transport of products on the United States’ border. This is a body that is obligated to safeguard any products that are transported to the United States with special focus on solid and hazardous wastes. The United States is focused on reducing entry of waste materials into the co untry as this will cause environmental threats. Any business that wishes to transport products from the border into the United States has to comply with the regulations that are highlighted by the Border Compliance Assistance Center. Similarly, this is an instrumental center where businesses gather information regarding transport from other places, which includes Mexico. Secondly, a business that would wish to import products into the United States has to comply with the Code of Federal Regulations (Weiss, 2011). These are the stated regulations that should be adhered to before starting any importation and exportation business in the United States. Compliance with the regulations requires massive preparation since they restrict

Operational Amplifier (Op-Amp) Lab Report Example | Topics and Well Written Essays - 2000 words

Operational Amplifier (Op-Amp) - Lab Report Example ed, high gain, voltage amplifier. They form the basis of a wide array of electronic circuits, including amplifiers, buffers, comparators, and analogue-digital/digital-analogue converters. An op-amp is represented in schematic notation by the following symbol: Figure 1 - Circuit Diagram Element Where V+ and V- are the differential inputs, VS+ and VS-, are the positive and negative supply voltages, and Vout is the output of the amplifier. While they are represented as a single element, op-amps are in fact composed of many circuit elements, and are conventionally sold as monolithically integrated silicon chips. 1.1 Origins and Development of the Operational Amplifier The operational amplifier can trace its origins back to fledgling telecommunications industry in the United States at the turn of the 19th century. With the invention of the telephone, there was demand to carry electronic voice communications over longer and longer distances. The challenge was to build signal repeating equi pment that minimized problems like distortion and crosstalk, so that multi-channel communications could be carried from one side of the country to the other. Advances in electronic equipment and amplifier design eventually led to the development of the first operational amplifiers at Bell Labs in the 1940s. Vacuum tube devices were essential to the development of amplifier technology, because they made possible for the first time the non-linear manipulation of voltage and current. â€Å"The Fleming Diode†, patented in 1904 by J.A. Fleming [1], was the first major breakthrough in this respect because it allowed for the rectification of current. Then in 1906, Lee De Forest [2] built upon this work with â€Å"The Audion†, a three-element triode vacuum tube that was the first device capable of signal amplification. Amplifiers built in the following years suffered from stability problems, as they used a positive feedback principle, and distortion due to the generation of ha rmonics by vacuum tubes. Harold Black [3], in 1927 while searching for a means of improving linearity and stability of currently-used positive feedback amplifiers, came up with the negative feedback amplifier principle. The idea of deliberately sacrificing gain in to improve stability ran counter to conventional ideas at the time, and it took 9 years for the original patent application to be accepted. Once implemented, however, the advantages of this approach quickly became clear. Within a few years the theory for stable amplifier design was formalized by Nyquist and Bode, two names now synonymous with fundamental electrical engineering principles, during their work at Bell Labs. At this

Beh 225 Appendix D Essay Example for Free

Beh 225 Appendix D Essay Sigmund Freud, is often described as the most famous figure in psychology. Hes written books on Hysteria; commonly being referred to as the father of psychoanalysis. His most popular works being highly influential on others that study psychology. unconscious, Psychosexual development (stages), Neurosis, transference and trauma are theories that Freud has developed over the years. One of Freuds theories was, that the personality is three structures. Another theory of Freuds was that our personality is rooted in the dynamics of the unconscious. He determined that the aggressive and sexual instincts were primarily unconscious drives which could determine our human behavior. Carl Jung is a psychologist that mostly studied the human psyche, dream analysis, and the collective unconscious. Cowgil (1997) refers, He proposed and developed the concepts of the extroverted and introverted personality, archetypes, and the collective unconscious. The issues that he dealt with arose from his personal experiences. For many years Jung felt as if he had two separate personalities. One introverted and other extroverted. This interplay resulted in his study of integration and wholeness. His work has been influential not only in psychology, but in religion and literature as well. She also believed that the unconscious mind had two separate components; the personal unconscious and the collective unconscious. Hall (1997) refers, Carl R. Rogers is known as the father of client-centered therapy. Throughout his career he dedicated himself to humanistic psychology and is well known for his theory of personality development. He began developing his humanistic concept while working with abused children. Rogers attempted to change the world of psychotherapy when he boldly claimed that psychoanalytic, experimental, and behavioral  therapists were preventing their clients from ever reaching self-realization and self-growth due to their authoritive analysis. He argued that therapists should allow patients to discover the solution for themselves. Rogers received wide acclaim for his theory and was awarded various high honors . Through Rogers extensive efforts in expressing his theory of personality through the publishing of books and lectures he gained a lot of attention and followers as well as those who strongly disagree with his theory of personality development. Reference Cowgil, Charles. Carl Jung, 1997. Part II Choose three of your favorite television characters; past or present. Complete the following matrix describing the characters’ personalities from the point of view of the three theorists, Jung, Freud, and Rogers. |TV Character |Jung |Rogers |Freud | |1. | | | | |2. | | | | |3. | | | |

Cellular Molecular Mechanisms Of Hutchinson Gilford Progeria Syndrome Biology Essay

Cellular Molecular Mechanisms Of Hutchinson Gilford Progeria Syndrome Biology Essay Hutchinson-Gilford Progeria Syndrome (HGPS or progeria) is a very rare autosomal dominant disorder which results in premature aging and eventually death. Patients are often very underweight at birth and will display conclusive symptoms of premature aging within 18-24 months, such as reduced body fat, hair loss and aged skin, alongside tissue and organ degeneration. Average lifespan for sufferers of HGPS is thirteen years and cause of death is invariably due to heart failure. Due to the nature of these symptoms, HGPS is referred to as an accelerated aging disorder. Currently, only 100 cases of HGPS have been formally documented, around 50 of which are children who are alive today; however it is estimated that a further 150 children worldwide currently suffer from HGPS, but have not yet been formally diagnosed. The identification of the HGPS mutation has only recently been identified and located on codon 608 of the LMNA gene, which codes for four types of lamin proteins: lamin A, lamin C, lamin Aà ¢Ã‹â€ Ã¢â‚¬  10 and lamin Cà ¢Ã‹â€ Ã¢â‚¬  2. These, along with the B-type lamin are responsible for keeping the structure of the nucleus together by forming a scaffold which lines and interacts with the nuclear membrane. The LMNA mutation leads to the expression of progerin, rather than lamin A, altering the structure of the nuclear membrane and leading to loss of nuclear integrity, DNA damage and a compromised DNA double-strand-break repair mechanism. This causes a variety of problems relating to normal cellular function as well as resulting in increased apoptosis and significantly decreased proliferation rates. Until recently, medical assistance for children with HGPS only involved treating the symptoms which accompany the disease, rather than the effects of the HGPS mutation; however in August 2009, clinical trials began testing the effects of farnesyltransferase inhibitors (FTIs) on HGPS patients. This was following experimental evidence from Toth et al (2005) who showed that human fibroblast cells expressing progerin had reversed nuclear alterations when treated with farnesyltransferase inhibitors in vitro. Introduction Aging is a normal and natural physiological process which all living things must experience, unless death should occur prematurely. Aging impairs verve and mobility, causes hair loss, weakens bones and inevitably will ultimately lead to death. As humans, the price that must be paid for our unique self-awareness is the knowledge that we will eventually age and die, forcing us to come to terms with our own mortality and compelling us to value youth. Patients suffering from HGPS are not given the opportunity to experience their youth in the same way as most. By 18-24 months their bodies are already showing signs of physiological aging and by 5 years old they will show more signs of age-related disease than many adults in their 70s. In young, healthy humans, cells are able to cope with the assault of DNA damage which all livings organisms will unavoidably encounter over time. Over time, the ability to deal with this damage lessens and the physiological process of aging will gradually occ ur. HGPS cells are not capable of dealing with this DNA damage to the same extent and so aging happens quickly and prematurely. Despite this, intelligence and cognitive function in children with HGPS are often above average compared to other children within their age bracket (Progeria Research Foundation, 2006). To understand the cellular and molecular mechanisms of HGPS, it is first important to understand the process of normal aging in healthy humans. Normal Physiological aging Aging on an evolutionary level may be described as a progressive decline in fitness (the ability to survive and reproduce) due to a decline in tissue functionality with increasing age (Partridge Gems, 2002). On a cellular level it may be described as a progressive functional decline and increase in cell mortality (Lombard et al., 2005). Although many theories have been proposed, no conclusive theory has been agreed upon to explain how or why we age. Aging is thought to be caused by various genetic and environmental factors. At the cellular level this progressive malfunction of tissue is thought to be due to accumulation of damage by various biomolecules which leads to cell loss or damage (Vijg, 2000). Usually the body has the ability to regenerate these damaged or lost cells through pools of stem cells, however the body does not have the ability to regenerate infinitely and over time this causes a decline in tissue functions typical of aging. This is consistent with the disposable soma theory of aging (Kirkwood Holliday, 1979), which states that cell repair and maintenance (including DNA repair, defence against oxidants, etc) are costly activities. To work to extend life indefinitely would make little sense, as in the wild many organisms have an extremely high mortality rate. Therefore, animals have evolved in such a way that energy invested in maintaining the soma is limited, so that the animal is kept alive long enough for it to reproduce, but not to keep it alive indefinitely. Past this point, the bodys regeneration mechanisms fail and physiological aging becomes apparent. From an evolutionary point of view, this theory makes more sense than others which are based around aging being a genetically inbuilt process, as this would provide no benefit whatsoever to the individual animal or the species as a whole. Aging may involve damage to a variety of cellular components; however damage to various DNA and RNA molecules is likely to be a major contributing factor. Despite the cells inbuilt mechanisms designed to repair damage, damaged DNA which has not been restored perfectly can lead to mutations with detrimental consequences. Balaban et al. (2005) outlines the potential role for damaged mitochondria DNA in the process of aging, however nuclear DNA is a more likely culprit. Mitochrondial DNA has thousands of copies present within the cell which can be replaced if damaged, whereas there are only two copies of nuclear DNA. Several studies have shown that as age increases, so does the risk of mutation (Martin et al., 1996) and there is substantial evidence to suggest a causal link between damage to nuclear DNA and physiological aging. Sedelnikova et al. (2008) showed that the level of double strand breaks (DSBs) that take place increase with age and older cells are less able to repair these DS Bs. Finally, there is the observation that symptoms of progeria are caused by defined mutations in DNA maintenance proteins, which leads to impaired DNA repair mechanisms (Musich Zou, 2009). HGPS belongs to a group of disorders known as segmental progeroid syndromes, characterised by early manifestation of features usually associated with normal physiological aging. They are consequently referred to as accelerated aging disorders. HGPS Background HGPS was first described over 120 years ago by Hutchinson (1886) and again later by Gilford (1904). Since its original classification in 1886, just over 100 cases of the disease have been documented. It affects around 1 in 4-8 million newborns all over the world with no preference for gender. Figure 1 Locations of children around the world who have been diagnosed with HGPG. There are currently 50 living children diagnosed with HGPS, most of whom reside in affluent Western countries. It is estimated that a further 150 children worldwide suffer from progeria but have not yet been identified due to insufficient means to diagnose in less prosperous countries as well as the rarity and complexity of the disease and the fact that the HGPS gene has only recently been identified. (Adapted from the Progeria Research Foundation, 2006) Children with progeria are often born appearing healthy, however shortly after birth it becomes apparent that weight and height gain are below that of which is expected of healthy children (Merideth et al., 2008). By 18-24 months of age they begin to display signs of premature aging, which can be seen in figure 2 below. Figure 2: A 3 and a half year old boy with HGPS showing typical progeroid symptoms. These include stunted growth, loss of hair and body fat, aged skin and unusually prominent eyes. Non-visible symptoms include stiff joints, atherosclerosis., osteoporosis and fatigue. Impaired growth does not seem to be due to any hormone inbalance/resistance or malnutrition. Cardiovascular problems are generally thought to be caused by loss of smooth muscle cells, disruption of the extracellular matrix and other irregularities in vascular structure. Life span ranges from 8 21 years with the average being around 13 years old. Death is almost invariably caused by atherosclerosis (Progeria Research Foundation, 2006). HGPS has recently been acknowledged as part of a family of diseases known as laminopathies, as it is caused by a dominant mutation on the LMNA gene. Before the identification of the gene responsible for progeria, diagnosis was carried out solely on the symptoms that have been mentioned. Thanks to the recent discovery of the mutated gene (Eriksson et al., 2003), diagnosis can be carried out based on the appearance of this mutation. HGSP is caused by a de novo mutation on the LMNA gene, although other progeroid syndromes may be hereditary. The lamins The LMNA gene codes for the nuclear A-type lamin proteins: lamin A, lamin C, lamin Aà ¢Ã‹â€ Ã¢â‚¬  10 and lamin Cà ¢Ã‹â€ Ã¢â‚¬  2 (Fisher et al., 1986). These, along with the B-type lamins are responsible for keeping the structure of the nucleus together by forming a scaffold which lines and interacts with the nuclear membrane. The structure of the nuclear lamina within the nuclear envelope is shown in figure 3. Figure 3: Structure and function of the nuclear lamina The lamina exists on the inner nuclear membrane (INM), providing structural support and helping with chromatin organisation as well as binding nuclear pore complexes (NPCs), nuclear proteins (purple) and transcription factors (pink). Barrier to auto integration factor (BAF) is a chromatin-associated protein which binds to the lamina and various nuclear envelope proteins (Coutinho et al. 2009) Fawcett (1966) deduced that the lamins are components of the nuclear lamina, a layer found between the chromatin and the nuclear envelope initially thought to provide structural support for the nuclear membrane and a location for the chromatin to attach. Recently, further roles of nuclear lamins have been proposed, including DNA synthesis, transcription, apoptosis and assembly of the nuclear envelope. It has been determined that several isoforms of lamins are encoded by three different genes: The LMNA gene encodes lamin A, lamin C, lamin Aà ¢Ã‹â€ Ã¢â‚¬  10 and lamin Cà ¢Ã‹â€ Ã¢â‚¬  2 and the LMNB1 gene encodes lamin B1 and LMNB2 encodes B2 and B3 lamins (Stuurman et al., 1998). Whilst every vertebrate cell expresses at least one type of B lamin, lamins encoded by the LMNA gene are only expressed in differentiated tissue. This observations suggest that lamin encoded by LMNA may have specific roles within certain cells. It is possible that the role of these lamins is in fact to induce or maintain differentiation within these cells, although no conclusive evidence has been presented to support this. It is likely, however, that A type lamins have roles related to and dependant on correct chromatin organisation and nuclear structure. This includes reformation of the nuclear envelope post-mitosis, transcription, DNA replication and nuclear positioning (Holaska et al., 2003; Spann., 20 02; Moir et al., 2000; Haque et al., 2006). Although studies have shown that LMNA deficient mice develop normally, shortly after birth growth problems occur (Sullivan et al., 1999). Shortly before cell division in the late prophase stage of the cell cycle, the phosphorylation of lamin subunits takes place, causing the nuclear envelope to break down. A-type lamins are the first to be disassembled, occurring during early prophase, whilst B-type lamins are disassembled during prometaphase (Georgatos et al., 1997). This course of action is thought to be a necessary requirement for the reassembly of the nuclear envelope after cell division have taken place (Burke and Gerace, 1986). However, studies such as those by Newport et al. (1990) have provided evidence against these theories, stating that when these disassembled lamin subunits are imported, they are done so into a formed nuclear envelope with fully functional pores. Perhaps is it possible that a finite number of lamin monomers are used in the reassembly of the nuclear envelope and the rest are transported in at a later stage. The role of lamins in DNA replication is unclear, however several studies have suggested that Xenopus interphase extracts were depleted of Lamin B3 which resulted in a lack of DNA replication (Newport et al., 1990), however it remained unclear whether this was entirely due to the absence of lamins or if other factors, such as a smaller and more fragile nuclear envelope, contributed. A later study by Moir et al. (2000) provided evidence to suggest that normal nuclear lamin organisation is required for DNA synthesis and that this dependency is completely unrelated to the insufficient formation of the nuclear envelope. It appears that when nuclear lamin organisation is incorrect, the elongation phase of replication fails to take place, probably due to an alteration in distribution of elongation factors, Replication Factor Complex and Proliferating Cell Nuclear Antigen. The potential role of nuclear lamins in transcription has been put forward by Spann et al. (2002), who disrupted the normal nuclear organisation of nuclear lamins using a dominant negative mutant lamin lacking the NH2- domain. This resulted in the inhibition of RNA polymerase II activity in both mammalian and embryonic Xenopus cells. Notably, RNA polymerases I and III were not affected. The role of lamins in apoptosis is directly related to the state of the nuclear envelope. Apoptosis is a very precise physiological mechanism for effective destruction of unwanted cells without causing inflammation or distress to other cells, as would occur in necrosis. Lamin degradation is one of the processes that occur during apoptosis, however several studies have suggested nuclear lamins play a role in the induction of apoptosis (Rao et al, 1996; Di Matola et al., 2001). Post mitosis, protein phosphatise 1 (PP1) is dispatched to the nuclear envelope to initiate lamin B reformation. If this process is abolished, lamin B is degraded and apoptotic signals take place. As previously mentioned, expression of lamins A/C is limited to differentiated cells. Due to their role in DNA replication and transcription, several researchers have hypothesised that they play a role in gene expression as well. Gupta and Saumyaa (2008) propose that specialised A/C lamin expression regulates gene expr ession in such a way which may prevent cell division and cause the cell to undergo terminal differentiation a form of programmed cell death. Lamins are also used for chromatin organisation and positioning within the nucleus, so cells with LMNA mutations exhibit a range of problems involving abnormal chromosome organisation. Glass et al (1993) showed that A lamins interact with chromatin by binding histones as well as indirectly through lamin-binding proteins such as LAP2ÃŽÂ ± and barrier-ro-autointegration (BAF) (Holaska et al., 2003). Cellular and molecular mechanisms of HGPS The most commonly reported mutation responsible for causing HGPS is LMNA  codon 608 in exon 11 (c. 1824 C>T). Although the LMNA gene encodes both A and C type lamins, only A lamins are affected as exon 11 is not present in lamin Cs. Whilst this point substitution does not result in an amino acid change (G608G ) it partially activates a cryptic splice site, resulting in the deletion of ~50 amino acids near the carboxyl terminal in lamin A (LAà ¢Ã‹â€ Ã¢â‚¬  50) but maintaining the CAAX site. Amongst the deleted amino acids is the ZMPSTE24 cleavage site, which is necessary for the maturation of lamin A. This results in farnesylation and carboxymethylation of lamin A, resulting in progerin (Capell et al., 2005). This cryptic splice site is only partially activated and it is estimated that only 10-50% of splices mRNA in transcribed. Since the second LMNA allele is normal, there is still some presence of wild-type lamin A although it is present in much lower levels. Whilst most HGPA pat ients are heterozygous for LMNA p.G608G, mutations have been reported on other location on the LMNA gene, such as one patient with a p. E145K mutation and another with 471C and R527C mutations (Goldman et al., 2002). These mutations have lead to various laminopathies very similar to HGPS (often referred to as atypical HGPS) however the pathophysiological manifestation of these diseases is probably different as they do not result in the production of progerin. HGPS cells are significantly larger than normal cells and usually have large cytoplasmic vacuoles, an abnormally shaped and sized nucleus, often distorted with chromatin extrusion (De Sandreà ¢Ã¢â€š ¬Ã‚ Giovannoli et al., 2003). Goldman et al. (2004) also report evidence of misshapen nuclear envelopes and abnormally thick lamina, both of which are associated with other mutations on the LMNA gene. Not surprisingly, these structural abnormalities cause a variety of cellular dysfunctions including loss of structural nuclear integrity and certain mitotic problems such as irregular chromosome separation, delays in cytokinesis and nuclear assembly and binucleation (Dechat et al., 2007). The loss of nuclear integrity can have a detrimental effect of the function of the cell, however it does not remove all structural ability of the nucleus and cell, it only reduces it. This means that the tissues most likely to be affected by a comprised nucleus are those which are consistently subjected t o mechanical stress, such as blood vessels. Indeed, vasculature in HGPS patients is often severely compromised and death is almost always caused by heart failure. HGPS cells have abnormal chromosome organization in interphase nuclei and can show a loss of peripheral heterochromatin, possibly due to various epigenetic changes. These include upregulation of genes such as H3K9me3 and H4K20me3, both of which are involved in the definition of constitutive heterochromatin (Columbaro, 2005). The H3K27me3, responsible for the definition of facultative heterochromatin, is downregulated, possible due to a reduction in the expression of the histone methyltransferase enhancer EZH2 used for H3K27 trimethylation (Schumaker et al., 2006). Evidence has suggested that these changes in heterochromatin due to altered gene expression may often result in further changes in gene expression. An interesting line of investigation to follow would be to monitor the expression of various other genes in HGPS cells. It is important to understand if HGPS enhances or inhibits the expression of various other genes and, if so, what these genes are and whether these genes play a part in the HGPS phenotype. Since lamin A only appears in differentiated cells, it is possible that one of the roles of lamin A is to maintain differentiation of the cells by securing tissue-specific gene expression. This could mean that the premature aging phenotype is not actually related to normal physiological ageing, but occurs due to certain tissues being unable to perform their designated function due to incorrect gene expression, leading to cell death, tissue degeneration and organ failure. Several studies have indicated that HGPS cells show increased damage to DNA. This was demonstrated by Bridger and Kill (2004) whose experiments showed that HGPS cells were unable to proliferate sufficiently when kept in culture and showed increased rates of apoptosis as well as demonstrating early signs of cellular aging. All of these afflictions are caused by damage to nuclear DNA. Liu et al (2006) also demonstrated that HGPS cells have increased activity in their DNA repair pathways, strongly implying that DNA damage has occurred. The most compelling evidence to suggest DNA damage as a likely culprit for progeroid symptoms is presented in a study by Liu et al. (2005), which showed that HGPS cells have a double strand break (DSB) repair defect. These cells show less concentrated levels of DSB repair factors such as Rad50 and Rad51 as well as damage signaling molecules such as 53BP1. With this evidence, the conclusion can be drawn that Lamin A in necessary for complete DNA repair to take place when necessary, and also that DSB repair is diminished in HGPS cells. DSBs are the most dangerous type of DNA damage that can potentially occur as a result of the constant attack from various agents, as they can potentially result in loss or confusion of genetic information or cell death. To some extent, DSBs occur naturally within the body during normal processes such as meiosis (Keeney Neale, 2006), or during replication when the separated stands encounter blocking lesions. The level of DSBs that occur during these processes can be increased by UV radiation, ionizing radiation, various chemical agents and the presence of free radicals. When a DSB occurs, the cells defense mechanisms commands that the cell cycle halts and DSB repair mechanisms activate. DNA DSB repair mechanisms are thought to occur as one of two processes: Non-homologous end joining (NHEJ) and homologous recombination (HR). Although HR is thought to be considerably more accurate than NHEJ, neither mech anism will produce perfect results. Evidence has been presented to imply that as we age we become increasingly dependent on HR to repair DSBs as activity of NHEJ and all other mechanisms gradually decrease (Johnson-Schlitz Engels, 2006). Many of the changes to the nuclear membrane are not a direct result of insufficient lamin A, but instead are caused by the presence of Progerin, an abridged version of lamin A, and its accumulation of the INM. This accumulation results in alterations in the structure of the nuclear lamina. Liu et al. (2005) suggests that the inefficient DNA repair mechanisms which occur in HGPS cells are in fact due to raised levels of Progerin at the INM. Fitting with this theory, experiments designed to reduce the levels of Progerin have successfully managed improve the cellular phenotype of HGPS cells. Scaffidi and Mistelli (2005) proposed inhibiting the production of Progerin whilst leaving lamin A unaffected by using specific antisense morpholinos which inhibit splicing at the deviant site. Another approach is to treat HGPS cells with farnesly transferase inhibitors (FTIs) which, as the name suggests, inhibit farnesyl transferase, so preventing the modification of Progerin to the farnseylated ki nd seen in HGPS cells. Liu et al., (2006) have shown that this approach does not only improve the cellular and nuclear abnormalities of HGPS cells, but can actually improve the health of HGPS mice. However, FTIs are not specific to Progerin as antisense morpolinos are, and lamin A is likely to be inhibited as well as the modification of Progerin. It is also possible that several other unrelated proteins would be affected by this approach; however these negative side-effects have not yet been documented. Several potential cellular and molecular mechanisms which may contribute to the HGPS phenotype are described below in figure 4. Figure 4 Various cellular and molecular mechanisms which may contribute to the HGPS phenotype. Progerin becomes trapped within the nuclear membrane as a result of permanent farnesylation. Alteration of the normal lamina structure causes vulnerability to mechanical stress and some nuclear blebbing. Other consequences involve disruption of protein interactions, disorganization/loss of heterochromatin and disrupted interactions with RNA polymerase II, RNA splicing factors and transcription factors, causing misregulation of gene expression. (Coutinho et al. 2009) The way these cellular abnormalities cause the general HGPS phenotype are not yet understood and currently can only be speculated on. As further research is carried out regarding HGPS, the cause of premature aging throughout the whole body may become more transparent. Treatment Due to the rarity and complexity of HGPS, there is currently no known cure; however, there are a variety of treatments aimed at alleviating the symptoms which are associated with this disease (Progeria Research Foundation, 2006). It is recommended that patients suffering from HGPS have a regular and nutritional diet as well as supplementary vitamin tablets (in normal doses). Dental problems which occur as a result of HGPS are treated with fluoride supplements, and aspirin should be administered on occasion in order to reduce the risk of heart attacks and strokes, which are invariably the main causes of death in HGPS children. In the case of heart-related problems such as angina, drugs like nitroglycerin may be used, although the dose should be measured carefully based on weight and height as use of anesthetics on children can be potentially dangerous. There is little that can be done to reduce the effect of reduced bone mass except for vitamin and calcium supplements, so children sho uld be accompanied at all times as they are at significantly greater risk of fracturing bones. The hip bones are particularly susceptible to dislocation due to coxa valga. Certain surgical procedures can take place to reduce the risk of this, as well as physical therapy in order to keep all joints as mobile as possible. The use of growth hormones has been suggested as a potential treatment for HGPS children; however the long term effects of this have not been shown to be significant. Currently there are several areas of research into possible clinical therapeutic treatments for progeria. Wang et al. (2008) and Liu et al (2006) demonstrated the use of farnesyltransferase inhibitors (FTIs) which appear to reduce the nuclear abnormalities present in HGPS cells, reducing the severity of symptoms on HGPS mice, improving their general health. Subjects showed improved cardiovascular health, a reduction in the number of bone fractures and improved survival and growth rates. This has been substantiated with evidence from Toth et al (2005) who showed that human fibroblast cells expressing progerin had reversed nuclear alterations when treated with FTIs in vitro. Clinical trials testing the effect of FTIs in children with HGPS began in August 2009 and ended the following December. Results from these trials are still being awaited. Summary Most of the breakthrough discoveries regarding HGPS have been made within the last few years. These include the location of the HGPS mutation, the nature of the disease and potential clinical therapies which are aimed at preventing the HGPS phenotype on a cellular and molecular level instead of simply treating the symptoms. There are several ways that the effects of the point mutation on the LMNA gene on chromosome 1 could lead to the pathogenesis of HGPS and it is likely that the combined affects of this mutation results in the HGPS phenotype. Compromised nuclear integrity may lead to reduced structural support for the cell, so those tissues under constant mechanical pressure such as the vasculature will suffer more greatly than other tissues. Another possible cause of the HGPS phenotype is the accumulation of DNA damage. This is a logical conclusion to draw, as the mechanism of normal human aging is thought to occur in this way. HGPS cells have insufficient DNA DSB repair mechanisms and so the phenotype of premature ageing in children with progeria is simply due to the magnification of one of the factors that causes aging in healthy humans. The pool of stem cells that healthy humans rely upon to counter increased apoptosis as a result of DNA damage would be under more pressure to proliferate in HGPS children, perhaps exhausting supplies and causing tissue degeneration. It is also possible that the stem cells themselves are affected by the HGPS mutation, causing a decline in proliferative ability. The possibility that the HGPS mutation may lead to up or down regulation of other genes is not one that should be ignored. If this is the case, the vast variety of symptoms which accompany HGPS may be explained by the altered lev els of expression of other genes. Until more is understood about Hutchinson-Gilford progeria syndrome, it is impossible to conclusively explain the extraordinary symptoms of this disease. Perhaps the results of the recent clinical trials will shed more light on how the alteration of two proteins due to a single point mutation can cause a child to show such drastic physiological aging. Experimental data analysis Programmed cell death (PCD or apoptosis) is a necessary part of complex life in all sorts of multicellular organisms. In humans, it is not only essential during embryonic development (preventing all manner of deformities) but also consistently through life. Efficient apoptosis prevents a vast number of diseases by ensuring that any unnecessary or potentially harmful cells are destroyed safely, without harmful effects on neighbouring cells, which happens in necrosis. Apoptosis only causes a diseased state when its rate of action exceeds or falls short of that which is necessary to keep an individual healthy. Insufficient apoptosis is well known culprit for the development of cancers, when tumorous cells which should have been erased are allowed to proliferate and develop into tumours. Another well known example of diseases due to lack of apoptosis is the vast number of immunodeficiency diseases caused by self-targeting T and B lymphocytes. These cells should have been removed through apoptotic signals, but when these signals fail these self-targeting lymphocytes are allowed to survive and will target the bodys own tissues. Increased rates of apoptosis throughout the body are commonly observed in many diseases, for example, HGPS. Abnormalities either within or external to the cell cause apoptotic signals to occur, resulting in PCD of cells which would otherwise not have been destroyed. PLAC8 (placenta-specific 8) is a gene which encodes a small, highly conserved protein known as onzin. Experimental evidence has been presented to demonstrate that under expression of endogenous onzin results in reduced cell proliferation, whilst over expression results in an increased cell count (Rogulski et al, 2005). This data suggests that onzin has a negative effect on the rate of apoptosis. Li et al. (2006) suggest that expression of onzin within a cell protects it from apoptotic signals and that when onzin levels are depleted the cell becomes sensitive to apoptotic assault. To test the effects of onzin on the rate of apoptosis, CEM-C7 T-leukemic cells were transfected with either an expression construct containing PLAC8 or pcDNA3, where the pcDNA3 vector acted as the control. Cultures of these cells where then exposed to a range of apoptosis-inducing agents: Fas, Dexamethasone (dex), cisplatin, butyric acid, okadaic acid and UV exposure. This was in order to determine whether expression of the PLAC8 gene effectively reduces the rate of induced apoptosis. Cell counts were taken after 24, 48 and 72 hours. The significance of the difference between cell counts in PLAC8 and pcDNA3 cultures when exposed to all apoptosis inducing agents was determined using a two-sample T-test. The samples used in each test were the apoptosis-inducing agent transfected with PLAC8 and the same apoptosis-inducing agent transfected with pcDNA3. The results from these two-sample T-tests are shown below in table I. Table I. Apoptosis inducer p-value (24 hours) p-value (48 hours) p-value (72 hours) Dex 0.023 0.069 Cisplatin 0.026 0.045 0.042 Butyric acid 0.003 Okadaic acid 0.03

political and pastoral in marvells poetry :: essays research papers

â€Å"A tension between the worlds of political engagement and private retreat† How distinct are the political and the pastoral in Marvell’s poetry The political and the pastoral certainly figures highly in Marvell’s poetry and often the two worlds become intertwined. Indeed, Marvell frequently utilises metaphors of nature to help convey and rationalise his political thoughts and feelings. With particular reference to the ‘mower’ and ‘Cromwell’ poems, I shall explore the relationship between the political and the pastoral in his work.   Ã‚  Ã‚  Ã‚  Ã‚  To begin, in the overtly political poem An Horation Ode upon Cromwell’s return from Ireland, Marvell begins by describing Cromwell emerging from a muses â€Å"shadow†, and â€Å"private gardens, Where he lived reserved and austere†. This, as the critic Friedman asserts, is a typical retreat of â€Å"poetic creativity†, and one often employed by Marvell. Indeed, in A poem upon the death of his late Highnesse the Lord Protector, Marvell presents a young Cromwell spending â€Å"pleasing hours† with his mother. The addition of a private presentation of Cromwell lends him a more human edge and helps us to understand his human weaknesses. In his Horation Ode, Marvell portrays Cromwell as a â€Å"flame of angry heavens† who â€Å"tis madness to resist or blame†. This lends Cromwell a godlike eminence or as Thomas. M. Greene asserts, puts him â€Å"beyond ethical categories†. However, Marvell continues that the â€Å"same arts that did gain a power, must it maintain†, i.e. the â€Å"inglorious arts† of war. The irony of comparing war, something primarily destructive, as an art, highlights the unease and possibly transient nature of Cromwell’s rule. Certainly, the fact that Marvell likens Cromwell to a Falcon, who once â€Å"having kill’d† seeks a â€Å"green bough† to perch on and then â€Å"the falconer has her sure†, shows that although he is strong, he cannot continue forever and will eventually be in some way controlled. Therefore, by utilising the idea of natural retreat, Marvell subtly asserts beneath the grandiloquent verse, the frailty and humanity of Cromwell existence.   Ã‚  Ã‚  Ã‚  Ã‚  Indeed the idea of the â€Å"green bough†, is a recurring notion in marvels poetry, and is often Connected with thought and retreat. In the epic poem Upon Appleton House Marvell seeks â€Å"sanctuary† in the woodland to â€Å"among the trees and birds confer†. This is something that the critic Friedman asserts as the â€Å"primeval unity of mind and nature†. This is amply supported by the line in Damon The mower, â€Å"My mind was once a true survey†¦ of all these meadows fresh and gay†, and further more

Expectancies As A Predictor Of Adolescent Alcohol Use :: essays research papers

INTRODUCTION This paper examines the use of an idea referred to as expectancy as a predictor of teen alcohol use. Expectancies are concepts that a society reinforces which go on to influence a person's behavior. Current clinical and field studies show that alcohol expectancies are reasonably accurate tools in estimating future drinking patterns. This paper sets out to determine the practical applications of this knowledge in the real classroom. HISTORY Prior to the early 1960s, virtually no clinical studies were available on the topic of teen drinking, as literature mostly focused on negative social and moral implications of the activity (Maddox and McCall, 1964). Contrary to somewhat popular notion, however, adolescent drinking is not unique on to the last few decades. In fact, the best indicators show that "drinking among youth has been a longstanding phenomenon" that has shown no significant change over the course of the last 120 years (Barnes, 1982). In the sixties, the issue grew in prominence probably due to the rise of the counterculture and an increase in teen drinking and driving accidents. A number of pioneering social scientists set out to determine basic information about the commonalty and frequency of alcohol use in this age group. Though specific data varied from study to study due to methodology and demographics, a striking picture emerged that "alcohol use is very prevalent among teenagers and young adults." In fact, Barnes (1982) co n Once research findings established the basic foundations, further questions soon arose on the psychological reasons behind the increase in consumption. Though the answers are still not definitive by any means, a few commonly accepted theories arose. Teens almost consistently report one of three reasons for drinking: partying, self-expression, and anxiety (Maddox and McCall, 1964). None of this information, however, is of particular alarm. Regardless of the reason, most adolescent drinkers consume only occasionally and generally responsibly (Barnes, 1982; Finn, 1979). In fact, a few authors contend that teenage drinking can be a fairly normal step in the process of identity development (Finn, 1979). "Drinking," claims Maddox and McCall (1964), "is important for validating their self-conceptions as adults or their claims to adult status." A great deal of controversy exists on whether time spent with peers in reckless activities such as drinking is a positive aspect of the socialization process as well. E PROBLEM DRINKING In the late 1970s and into the 1980s researchers begun to realize that they had not designed their studies to examine this much more destructive phenomenon of problem drinking.

Analysis of Wallace Stevens 13 Ways of Looking at a Blackbird :: Wallace Stevens 13 Ways Blackbird Essays

Analysis of Wallace Stevens' "13 Ways of Looking at a Blackbird"   Ã‚  Ã‚  Ã‚  Ã‚  'Thirteen ways of looking at a blackbird' by Wallace Stevens is a poem about what it means to really know something. In this poem, Stevens shows this connection by writing a first person poem about a poet's observation and contemplation's when viewing a blackbird. He does this by making each stanza an explanation of a new way he has perceived this blackbird. First, he writes about his physical perception of the blackbird as an observer. Then, he writes about his mental processes during this time. These are as the thoughts and perceptions of the blackbird itself, as what it must be like to be that bird. By the end, he has concluded that by seeing this blackbird, a connection has been made and he now knows the blackbird has becomes a part of him.   Ã‚  Ã‚  Ã‚  Ã‚  In the first stanza, he focuses on the eye of the blackbird as an outside observer. This symbolizes the thoughts and the consciousness of the blackbird. It is also a transition from the observer's perception to the blackbird's perception. In the second stanza, Stevens goes on to say that he was of ?three minds, Like a tree, In which there are three blackbirds.? This was the first time he makes the connection between seeing the blackbird and him himself metaphorically being the blackbird. He makes this connection even more clear in the fourth stanza when he says that ?A man and a woman Are one. A man and a woman and a blackbird are one." In the sixth stanza he goes back to being the poet observer as he watches the blackbird fly by his icy window. Again in the next stanza he goes back to the point of view of the blackbird wondering why the men of Haddam only imagine golden birds instead of realizing the value of the common blackbird. At this time, he makes the connection that in seeing and knowing the blackbird it becomes a part of himself. When he says in the eighth stanza ?I know noble accents And lucid, inescapable rhythms; But I know, too, That the blackbird is involved In what I know.? he is acknowledging that he is still a poet but when he sees, thinks, and writes about the blackbird, in a way he is also the blackbird. After this, the black bird and the poet observer are separated but in the twelfth stanza Stevens writes ?The river is moving. The blackbird must be flying.? This is meant to show that though the observer's

A Futile Task- the Catcher in the Rye Essay

The teenager stands on a hill in complete solitude, watching the nearby football game, and contemplating if he should say a final farewell to the school. Ambivalent, the melancholy teenager leaves himself in a confused and vulnerable position to the lonely and corrupt reality of the world. In an attempt to endure the vices that alter the blissful spirit, he feels the need to make things right by saving what little recognizable evidence of purity that the world has not already desecrated. All throughout the novel The Catcher in the Rye, author J. D. Salinger establishes Holden’s bizarre attraction toward particular places, objects, and experiences, past and present. The author concurrently sets out the subtle, tender concern that Holden has for the preservation of innocence and where life will ultimately end up. At essential points in the plot, Salinger embodies these two motifs, which metaphorically represent each other, in order to uncover the true sadness that lurks in an abandoned Holden. By doing this, the author reveals the greater theme that unlike artifacts of history, constrained the human spirit would severely stunt any opportunity of development for people. Salinger constantly highlights the motif of Holden’s endeavors to preserve innocence from being tainted by corruption. The author first presents this through the objects that Holden develops a bond with. To demonstrate that bond, Salinger produces a scene in which Holden visits his old teacher, Mr. Spencer, one of the few concerned about the boy. The teacher asks Holden to read his paper about Egyptian mummifying aloud. Salinger first demonstrates Holden’s obsession for the preservation of life when Holden divulges that â€Å"Modern science would still like to know what the secret ingredients were that the Egyptians used when they wrapped up dead people so that their faces would not rot for innumerable centuries† (Salinger 16). Implying the deep interest that Holden possesses for this subject, Salinger underscores that the teenager may have experienced a harrowing event relating to the matter. Because Holden would still dearly like to know the â€Å"secret† of maintaining life in such a state, the author also exposes Holden’s unawareness of the topic altogether. Leaving Holden in an unaware state, the author then inserts the minor motif of Holden’s younger brother’s baseball mitt to clear the confusion. When asked to write a composition for a classmate, of all the topics Holden decides to write about, the nostalgic adolescent distinguishes his younger brother’s baseball mitt. With this sacred object, Salinger links it to Holden’s goal for conserving the unharmed and the aesthetic, as the glove had poems scribed all over it in ink. The author represents the ink as the permanence in which the item endures. Similar to the beloved baseball mitt, Holden finds solidity in a Little Shirley Beans record that he purchases. Identifying the song eternally preserved on the record, the writer elucidates that Holden still preserves things in the state that they are left, never allowing them to change. Salinger also represents Holden’s remembrance of the innocence of childhood, the record reminding him of that period. In addition to the revered objects, the author exhibits a pattern in Holden’s experiences and anecdotes that motivate Holden in the direction of making events like those last for an eternity. One of Holden’s recollections that Salinger touches on briefly involves Holden playing checkers with a childhood friend, Jane Gallagher. At one point in the game, Jane cries, and sensing this, Holden drives his efforts to console with her, kissing her all over her face, avoiding her mouth. Symbolizing the need to protect Jane and her virginity, the author portrays Holden comforting her instead of violating her, revealing the tender empathy that Holden possesses. Prior to reflecting this memory, Holden underwent an instance of rejection at a bar, and seeing what little empathy people have, Holden tries to remember a positive memory to keep his motivation alive. One of Holden’s fondest memories stems from the remembrance of his younger brother. When given time to ruminate upon his past, Allie stands out as the ideal brother that Holden would never find in any other person. Salinger distinguishes Allie as â€Å"terrifically intelligent† and that â€Å"he was also the nicest†¦ he never got mad at anybody. People with red hair are supposed to get mad very easily, but Allie never did, and he had very red hair† (Salinger 50). Portraying Allie as the epitome of childhood innocence, the author juxtaposes this to Holden’s thoughts of preserving purity. Because his sibling passed away at an extremely young age, Holden’s sole coping strategy involves the thought of bringing back his brother, thinking that someone as magnanimous as Allie deserves to live on. Despite Holden’s naive point of view toward what troubles him, he finally begins to subtly realize something about his brother. Salinger weaves a scene of Holden conversing with Phoebe, his younger sister, and the teenager mentions that he loves Allie, thinking that he still exists. Following Phoebe’s comment that Allie is dead, Holden refuses to accept and reveals that â€Å"Just because somebody’s dead, you don’t just stop liking them, for God’s sake—especially if they were about a thousand times nicer than the people you know that’re alive an all† (Salinger 223). Salinger highlights a rare moment: someone offering guidance to Holden, accepting that he is stuck. By displaying Holden touching upon Allie, Salinger expresses the adolescent beginning to address the connection with Allie. However, Holden still possesses the unawareness to come to terms with this. Salinger effectively amplifies the essence of Holden’s being in a thought of the teenager. The author illustrates a dream of Holden desiring to catch children who accidentally fall off the ledge of a cliff in the rye field, the adolescent defining himself as a catcher in the rye. The author resembles Holden as a selfless martyr in this thought, leaving Holden in bliss that he can save people if they fall; the author makes clear that, for Holden, danger should be avoided by all means and at all costs. Salinger stems the implication from Holden’s own dealings with losses Perhaps the most important category that Holden associates with conservation and longing consists of the places that he visits. One of the first locations that Salinger introduces pertains to the museum, a site of never changing exhibits. The boy favors that all the displays stay the way they are and that things are kept in fixed positions. By symbolizing the museum as a place where nothing changes, Salinger mirrors the setting to Holden’s opposition to growing up and change. Salinger initiates the beginning of a epiphany for Holden when the teenager travels to his old elementary school to meet with Phoebe. The writer describes the school as familiar to Holden While appearing to give up hope on the world, Holden sees yet another instance of chicanery. The author depicts an obscenity on the wall that appalls Holden, and in the act he makes of rubbing it out, Salinger reiterates Holden as a savior figure and that combating all of evil can be accomplished. The author furthers the learning experience for Holden when the teenager returns to the museum. Although feeling tranquil while all alone in one of the showcases, Holden observes yet another contemptible obscenity, defacing one of the glass cases. By repeating the obscenity for Holden, Salinger starts to affirm in Holden that he cannot keep everything clean and pure but must accept events like these once in a while. Finally pivoting Holden’s vague realization to the last crucial place, Salinger fleshes out the epiphany. Accompanied by phoebe, Holden views one of the carousels nearby, his attraction to it brought on by the fact that the ride always plays the same song. Holden again clings to a familiar tangent and what comforts him. Yet, the teenager watches Phoebe go around on the carousel and sees her and other children trying to grab for the gold ring. Salinger depicts Holden as â€Å"afraid that she’d fall off† but he does not react, as Holden realizes that â€Å"If they fall off, they fall off, but it’s bad if you say anything to them† (Salinger 274). Paralleling and directing opportunity and danger close together, Salinger enables acceptance in Holden that if people stay the same way, there leaves no room for development, thus rendering them static, strayed from the dynamics of change, and this time, Holden does not deny Phoebe or himself the opportunity to mature.

Psychology Vocabulary

Psychology (Myers, 8E) Chapter 10 dissect online at quizlet. com/_h108 1. cognition the kind activities associated with thinking, knowing, remembering, and communicating a psychological grouping of standardized objects, events, ideas, or people a mental im climb on or best spokesperson of a category a methodical, synthetic rule or procedure that guarantees solvent a component particular puzzle.Contrasts with the usually speedier still also much error-prone -use of heuristics a simple thinking strategy that a great deal allows us to make judgments and solve problems expeditiously usually speedier but also to a greater extent error-prone than algorithms a sudden and frequently novel realization of the solution to a problem it contrasts with strategy-based solutions a tendency to inquisition for breeding that confirms ones preconceptions the inability to see a problem from a new location an bank check to problem solving a tendency to approach a problem in a particular wa y, oft a way that has been successful in the past the tendency to think of things wholly in terms of their usual functions an impediment to problem solving judging the likelihood of things in terms of how well they appear to represent, or match, particular tropes may expand one to ignore other relevent information estimating the likelihood of events based on their availableness in memory if instances come promptly to mind (perhaps because of their vividness), we presume such events be common the tendency to be more confident than correct to overestimate the true statement of ones beliefs and judgments the way an come forward is posed how an issue is framed can significantly make decisions and judgments 15. belief bias 2. concept prototype algorithm he tendency for ones exist beliefs to distort logical reasoning, sometimes by making invalid conclusions seem valid, or valid conclusions seem invalid clinging to ones initial conceptions after the basis on which they were for m has been discredited our spoken, written, or signed row and the ways we combine them to communicate implication in a nomenclature, the smallest distinctive sizeable unit of measurement in a language, the smallest unit that carries meaning may be a word or a part of a word (such as a prefix) in a language, a carcass of rules that enables us to communicate with and understand others the flummox of rules by which we derive meaning from morphemes, words, and sentences in a disposed(p) language also, the consume of meaning the rules for combining words into grammatically sensible sentences in a given language beginning at slightly 4 months, the wooden leg of name and address evolution in which the infant spontaneously utters dissimilar sounds at first unrelated to the abode language the stage in speech phylogeny, from about age 1 to 2, during which a child speaks generally in maven words beginning about age 2, the stage in speech development during which a child speak s mostly two-word statements other(a) speech stage in which a child speaks like a telegram go car using mostly nouns and verbs and omitting auxiliary words Whorfs hypothesis that language determines the way we think 16. 3. belief continuity language 4. 17. 18. phoneme morpheme 5. heuristic 19. 20. grammar 6. insight 21. semantics 7. bank check bias fixation 22. syntax 8. 23. 9. mental set babbling stage 10. working(a) fixedness representativeness heuristic 24. one-word stage two-word stage telegraphic speech linguistic determinism 11. 25. 26. 12. handiness heuristic 27. 13. overconfidence 14. framing

American Liberty: From Past to Present

freedom is a purpose that is comm nevertheless used by the average the Statesn in his daily affairs. A lexical definition of self-reliance states that it refers to the freedom to intrust or act without the restriction of an unnecessary force. As far as the psyche is concerned, self-reliance is the aptitude of a person to act according to his will. solely do we really fuck the accounting of Americas emancipation? Do we really actualize the historical rasets that capture shaped the intimacy that we know of and enjoy in these contemporaneous ages?In this paper, I will be examining the roots of Ameri advise indecorum from the base era to the modern debates contact the concept of casualness. I will also be looking into the prop onenessnts of liberty and those who do sh atomic number 18d a world-shattering role in defining and upholding liberty as we know it today. The design Era Hundreds of historic period in the lead today, America was an entirely different place . readable before the creation of the piece, different European countries have already established their suffer settlements across America. The Spaniards and the cut were among the beforehand(predicate) colonizers until the quantify of the British.During the rule of the British conglomerate, atrocious shortage in human labor resulted to captivity and obligate servitude of the natives. In the geezerhood that deciphered, conflicts broke-out between the autochthonous Ameri rouses and the side of meat settlers. It should be noted, however, that Virginia already had black indentured servants in 1619 subsequently being settlight-emitting diode by Englishmen in 1607 (Virginia Records Timeline 1553-1743, http//memory. loc. gov/ammem/collections/jefferson_papers/mtjvatm3. html), thereby suggesting that the attainment of genuine liberty from the colonizers is that to be realized.It is perhaps during the time when the English pilgrims came to Plymouth, Massachusetts in 1620 an d established their colonies that the concept of liberty came about, not the least in the context of the pre- musical composition invoice of America. As Mark Sargent writes in his article The standpat(prenominal) plight The Rise of the Mayflower Compact in American Myth, some of the passengers in the Mayflower place who were not travelling to the saucy World for spectral reasons would insist upon complete freedom when they stepped ashore since the New World is already outside the territory c over in their patent from the British cr give birth (Sargent, p.236). After the septette Years War between the British forces and the confederation of French and American Indian forces in 1763, the British Empire enforced a series of taxes on the Americans so as to cover a voice of the cost for defending the colony. Since the Americans considered themselves as subjects of the King, they understood that they had the analogous secures to that of the Kings subjects alimentation in stri king Britain.However, the Sugar Act, Currency Actboth passed in 1764the Stamp Act of 1765, the Townshend Act of 1767, to name a few, compelled the Americans to take drastic measures to send the message to the British Empire that they were being treated as though they were less than the Kings subjects in outstanding Britain (Jensen, p. 186). Moreover, the taxes were enforced despite the lack of representation of the American colonists in the Westminster Parliament.One of the famous protests taken by the Americans is the capital of Massachusetts Tea Party in 1773 where numerous crates containing teatime that belonged to the British East India Comp any(prenominal) were destroyed aboard ships in Boston Harbor. As a result, the British political science passed a series of acts popularly cognise as the Intolerable Acts in 1774, further fanning the festering oppression felt by the American colonists. Eventually, the American rotary motion ensued come outning in as early as 1775 when British forces confiscated arms and arrested r developmentaries in Concord, thereby sparking the first hostilities after the Intolerable Acts were passed (Jensen, p.434). From 1775 to 1783, the colonies that formed their own independent states fought as one as the bakers dozen Colonies of noth America. Lasting for roughly eight years, the American renewalary War ended in the confirmation of the Treaty of Paris which formally recognized the license of America from the British Empire. Between these years, the colonies underwent several changes which cook fargonwell of the developments toward the framing of the validation (Bobrick, p. 88).One of these changes is the shift towards the word sense of notable res publicaan ideals, such as liberty and nontransferable rights as core values, among several members of the colonies. Moreover, the republican ideals of the time saw corruption as the sterling(prenominal) of all threats to liberty. In essence, the concept of liberty duri ng the fundament era revolves around the liberation of the American colonies from the British Empire and the growing oppression it gave to the colonists finished tax burdens and a series of repressive acts.For the American colonists, liberty meant the severing of its ties from the British governance activity and the creation of its own independent nation recognized by an early(a)(prenominal)(a) countries. The pen and check of the brass On the quartern of July in 1776, the second Continental Congress write and officially select the United States Declaration of liberty which established the separation of the thirteen American coloniesthe colonies which were at war with Great Britain from 1775from the British Empire.Although other(a)s say that the founding moment of America is not on July 4 only twain eld earlier (Groom, http//independent. co. uk/arts-entertainment/books/ go over/the-fourth-of-july-and-the-founding-of-america-by-peter-de-bolla-455878. html), it anticip ates a fact that there came a point in time when America make uptually decl atomic number 18d its liberty. The evolution of American organizational possibilityespecially that which is concerned with libertycan be unwrap understood during the confrontation over the writing and the ratification of the Constitution.In fact, the Declaration asserts that pot have inalienable rights which include life, liberty and the pursuit of happiness. The Articles of alignment served as the constitution which governed the thirteen states as ploughshare of its fusion called the United States of America. After being sign in 1781, the United States of America was brought as a political union under a henchman political sympathies in fix up to defend better the liberties of the people and of each state. Meaning, each state contain its independence and independentty despite being politically held together as part of the union.However, the Articles were not without competition and criticism s from several notable political turn overers of the time. For example, pack capital of Wisconsin saw several main flaws in the Articles of Confederation that were alarming, or threatened the very existence and habit of the Articles first and foremost. For one, capital of Wisconsin was concerned about the dangers present by the divided republics or factions accustomed that their post may stand in conflict to the interests of others. Madison argues in The Federalist, specifically in Federalist no.10, that in parliamentary procedure to shelter the citizens from the dangers posed by these psyches who have contradicting interests, a large republic should be created, a republic that will safeguard the citizens from the practicable harms brought by other states. It is likewise grave to note that the union is not a homogenous group of citizens with the same political inclinations. Madison also argues that for the giving medication to become potent it needs to be a hybrid of a national and a national constitution.The governing body should be balanced in the sense that it should be federal in some aspects and republican in others sort of of giving more weight to each recount state over the larger republic. In his Federalist No. 39, Madison proposes and describes a republic government manoeuvre by three fundamental principles the derivation of the governments legitimate power through the harmonize of the people, representatives elected as administrators in the government, and a confinement on the length of the terms of service rendered by the representatives (Kobylka and Carter, p.191). Madison also pointed out in Federalist No. 51 that there should be checks and balances in the government, specifically among the judicial, legislative and the executive branches. The judiciary, therefore, is at par with the other twain inasmuch as each of the other two are at par with one another. enceinte one of the three more powers disables the other two to check if that branch is still functioning in spite of appearance its perimeters.As a result, the more powerful branch becomes a partisan branch which consequently creates dangers to the liberties of the people. Another important part of the evolution of American political opening is the contention raised by Patrick total heat. In a letter sent to Robert Pleasants in January 18, 1773, Patrick Henry sees the family between the youthful government and the institution of slaveholding as a contradiction precisely because speckle the new government is said to be founded on liberty, there the evil that is thraldom persisted under the new government.During those times, thralldom was not yet abolished and that the new government was unable to meet the challenge of living up to its roles and foundations by failing to address the institution of thraldom and demolishing it altogether. Moreover, Henry understood the efforts of secession from the custody of England were a press of freedom or slavery, which can also be looked upon as a drumhead of either a freedom from or a continuation of tax slavery from the British.While Madison was part of the Federalists who were supporting the ratification of the Constitution, the Anti-Federalists apparently argued against its ratification. It was Patrick Henry who led the group in criticizing the contents of the proposed Constitution. For instance, Henry argued that the articulate We the People in the Preamble of the Constitution was misleading primarily because it was not necessarily the people who hold and created the proposed Constitution but the representatives of each participating state.Thus, Henry argues that the Preamble should instead read as We the States which in turn delegated power to the union. Another argument of the Anti-Federalists is the acquire that the central government and, therefore, the central power aptitude result to a revival of the monarchic geek of rule reminiscent of the British Empire which the Patriots fought. The revere is that, by delegating a considerable kernel of power to the central government, the liberties of the individual states and the people are weakened as a result.Nevertheless, the Constitution was adopted on September 17, 1787 and later ratified in each of the state conventions held. The anti-federalists share a significant role in strengthening some of the points of the Constitution through the bring home the bacon amendments. The first ten amendments to the Constitution are popularly known as the aviator of Rights it is largely influenced by the arguments of the anti-federalists. For the most part, the superlative of Rights aimed to batten down that Congress shall not create laws which stand against the rights and liberties of the citizens of the nation.In effect, the Bill of Rights limits the power of the federal government in order to secure the liberties of the people in the United States. In Federalist No. 84, Alexander Hamilton argues agai nst the Bill of Rights for the reason that the American citizens will not have to necessarily declension their rights as a result of the ratification of the Constitution and, thus, the defendion of the rights through the Bill is unnecessary. Moreover, Hamilton also argues that creating a Bill of Rights would effectively limit the rights of the people since those that are not listed in the Bill will not be considered as rights.In response to the argument, the Ninth Amendment to the Constitution was introduced and ratified later on. The amendment specifically states that the rights of the people are not to be limited to those which are listed in the Constitution. As it can be observed, the time before and during the ratification of the Constitution and the succeeding amendments make fall how the people at the time sought to protect the liberties that they have realized and gained after the American Revolution and the defeat of the British Empire.Moreover, the debates at that time turn around the issue of what to do with the liberties gained and how to secure them for the attack generations. One sidethe Anti-Federalistsargues that the central government weakens the independence and sovereignty of the states as well as the rights and liberties of the people. The other sidethe Federalistsargues that the Constitution will help husband and strengthen the Union. Modern debates In the years that followed, debates over the interpretation of the Constitution, the role of the government and the place of the individual in American society have escalated.In his testify resistance to Civil Government (popularly known as Civil noncompliance) first published in 1849, Henry David Thoreau asserts that the people should not simply abide passive and allow the government to be an federal agent of injustice. Much of Thoreaus political beliefs eventually follow that same philosophy. In his work Walden published in 1854, Thoreau attempts to live a life of loneliness in a c abin, away from the reaches of the society. In one of his days in Walden, Thoreau was arrested for the charge of not paying his taxes. His falsifying was that he refuses to pay federal taxes to a government that tolerates slavery.In essence, the fact that Thoreau decided to stay in solitude for approximately two years (although the contents of Walden was made to appear as though all the events happened within just a year) signifies his decision not to accommodate to the dictates of the society. On the contrary, Thoreau lived a life of liberty, free to do anything that he chooses without the institutions of society restraining him. The same sentimentnon-conformity or disobedience to the dictates of the society, especially the governmentechoes through in Thoreaus other work, which is Civil Disobedience.Thoreau asserts that the only obligation which I have a right to assume is to do at any time what I think is right (Thoreau, http//sniggle. net/experiment/index. php? entry=rtcgp04). That passage, along with the rest of Civil Disobedience and its theme in general, implies that people have an inseparable liberty, which is the liberty to do any time what they think is right. Taken altogether in the context of the concept of liberty, Thoreau seems to suggest that people ought to disobey a government that oppresses other people since each individual has inalienable rights that nobody can take away, not even the government.In the face of oppression such as slavery (which was still very much a part of America within twenty years after the ratification of the original Constitution since the issue of slavery was a very delicate and agonistical matter during the Philadelphia Convention), Thoreau even suggested that Abolitionists should not only confine themselves with the clean musical theme of abolishing slavery but resisting the instructions of the government such as paying taxes.Thus, as a reading of Thoreaus works would suggest, to have liberty is to act upon cr ucial issues instead of passively allowing contentious actions of the government to thrive and continue. I cannot help but think that Thoreaus concept of liberty is something that is absolute, which I also take to mean as captive only within ones temperament instead of being limited by the government. Moreover, since Thoreau suggests that liberty is doing any time what one thinks is right an individual should first know if what he or she thinks is therefore right instead of being wrong.Charles Madison notes that Thoreau was severely concerned with the ever pressing problem of how one might earn a living and remain free (Madison, p. 110). I cannot help but begin to think that Thoreau attempts at embodying and enacting his individualistic beliefs. As Leigh Kathryn Jenco argues, The speculation and practice of democracy fundamentally conflict with Thoreaus conviction in moral autonomy and scrupulous action (Jenco, p.355) democracy is essentially the rule of the majority which con sequently ignores the decisions of the minority. However, I think that much of Thoreaus thoughts were heavily influenced by the circumstances during his time. His aversion towards the oblige taxation policy of the government stems from the fact that the government at that time still tolerates slavery which is without delay against an individuals liberty.Thoreaus insight on the perceived conflict between the liberties being upheld by the Constitution and the actual state of the government during his time points us to the ideal that the people are sovereign because the people is the ultimate source of power of the government. If it is thence the case that the Constitution upholds the rights of individuals including the right to liberty, it seems appropriate to consider as well why slavery at that time was not immediately abolished entirely especially at the time when the Constitution was ratified.In fact, it was only in 1865 under the Thirteenth Amendmentabout 80 years after the or iginal Constitution was adoptedwhen slavery was legally abolished and when Congress was given the power to ultimately enforce abolition. During the time when slavery was not yet abolished and immediately after the original Constitution was ratified, it can be said that not all citizens living in America were given full liberties. several(prenominal) people were still laboring as slaves to their American masters.That is perhaps an often neglected piece of history that undermines the spirit of creating a Constitution and a government that will uphold the rights of the people. The pre-American Revolutionary war, the founding era, the ratification of the original Constitution, the creation of the Bill of Rights and the other succeeding amendments to the Constitutionall these stand as testimonies to the evolution of American political thought. The concept of liberty has vie an important role in the development of the federal government and the Constitution.Although the history of Ameri can political thought might reveal that the attainment of liberty through the years has never been a smooth journey, contemporary America has reaped a large amount of benefits from the sacrifices and ideas of the Founding Fathers and all the people who lived and died during those times. Some might even argue that liberty is yet to be in truth achieve in todays American society. But if liberty is yet to be attained in practice, how is it possible that people are given the right to air their grievances before the government?How is it possible that people have the liberty to do as they please so long as what they do does not conflict with what is legal? In any case, the present American Constitution guarantees the liberty of the people and that there are institutions which seek to promote and guard that important right. Had it been the case that the early Americans swallowed everything that the British Empire throw in their way and that the Founding Fathers creaky the creation and am endment of the Constitution, the United States of America would not have been the land of the free and the home of the brave.Works Cited Bobrick, Benson. Fight for freedom The American Revolutionary War. 1st ed. New York, NY Atheneum, 2004. Groom, Nick. The fourth part of July and the Founding of America, by Peter De Bolla. 2007. Independent. Co. Uk. October 16 2008. . Hamilton, Alexander, James Madison, and John Jay. The Federalist, on the New Constitution. 1787. October 18, 2008 . Jenco, Leigh Kathryn. Thoreaus reassessment of Democracy. The Review of Politics 65. 3 (2003) 355-81. Jensen, Merrill. The Founding of a Nation A History of the American Revolution 1763-1776. Indianapolis, IN Hackett Publishing Company, 2004. Kobylka, Joseph F. , and Bradley Kent Carter. Madison, The Federalist, & the Constitutional Order piece Nature & Institutional Structure. Polity 20.2 (1987) 190-208. Madison, Charles. Henry David Thoreau incomprehensible Individualist. Ethics 54. 2 (1944) 11 0-23. Sargent, Mark L. The Conservative Covenant The Rise of the Mayflower Compact in American Myth. The New England Quarterly 61. 2 (1988) 233-51. Thoreau, Henry David. Resistance to Civil Government. 1849. October 18 2008. . Virginia Records Timeline 1553-1743. The Library of Congress. October 17 2008. .